In Vitro Fertilization (IVF)

Since the birth of Louise Brown, the first in vitro fertilization (IVF) baby, dramatic developments have occurred in IVF. IVF was initially designed to overcome the problem of tubal infertility but is now widely held to represent the treatment of choice for unexplained infertility, male factor, endometriosis, and ovarian dysfunction resistant to ovulation induction.

Insemination

Insemination can be performed conveniently in one of several configurations. Multiple oocytes can be preincubated four hours after collection and inseminated in culture dishes with normospermic males, the insemination concentration is equivalent to 50,000-100,000 sperm per one oocyte.

IVF indication

• Tubal pathology

• Male infertility

• Endometriosis

• Cervical factor/immunological infertility

• Hormonal disturbances

• Unexplained infertility

Outcomes of IVF pregnancies

Babies born through IVF procedures exhibit no greater incidence of congenital malformations nor developmental problems than do naturally conceived children in the general population when matched for plurality and gestation.

References

Lucinda L. Veeck , MLT, hDSc. An Atlas of humangametes and conceptuses ; 54

David K Gardner, DPhil. Textbook of assisted reproductive techniques: laboratory and clinical Perspectives. 1 st ed. United kingdom. Taylor & Francis. 2001.; 94-97,393-400